From Micromagnetic to In Silico Modeling of Magnetic Nanodisks for Hyperthermia Applications

Abstract Magnetic nanodisks have been recently proposed as biomedical tools for therapeutics at the nanoscale level, with a special focus on hyperthermia cancer cure. Here we present detailed study of permalloy to be used in alternative superparamagnetic iron oxide nanoparticles, efficient heating agents that release heat via magnetic hysteresis. A micromagnetic modeling analysis is carried out identify sizes and ac field parameters maximize specific loss power (SLP), guaranteeing fulfillment biophysical constraints (Hergt–Dutz limit) vortex state remanence (reduced agglomeration effects). The highest SLP (790 W g −1 ) found 100 nm diameter 20 thickness nanodisks, excited frequency 75 kHz. Further elucidates influence magnetostatic interactions local nanodisk‐field orientation nanodisk clusters, which originate from deposition target tissues. At high concentrations, can lead reduction 40–50% hysteresis losses. From thermal simulations, finally demonstrate murine model temperature increments comparable obtained calorimetric measurements under quasi‐adiabatic conditions achieved only by using an order magnitude larger dosage due blood perfusion effects.